To determine the safety of Vetradent™ Water Additive in dogs, a controlled, randomized Good Scientific Practice (GSP) study was performed. The study was conducted over 30 days with one
control and two treatment groups which received 1X or 5X the recommended Vetradent™ dose.
Clinical observations, oral assessments, body weight measurements, and clinical pathology
analysis were performed during the study. Dogs were observed daily for food intake, general appearance, and feces. Bi-weekly body weight measurements were taken, and samples for blood, serum, and coagulation were collected on days 1, 14, and 29.